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Lack of Dependence on p53 for DNA Double Strand Break Repair of Episomal Vectors in Human Lymphoblasts

โœ Scribed by Manu Kohli; Timothy J. Jorgensen


Book ID
115584671
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
145 KB
Volume
264
Category
Article
ISSN
0006-291X

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The initial step of the V(D)J recombination occurs through the generation of a DNA double-strand break (dsb). Defects in the DNA-dependent protein kinase complex (DNA-PK) result in an inability to perform either V(D)J recombination or any dsb repair effectively. The human autosomal T-B-severe combin