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Lack of correlation between repair of DNA interstrand cross-links and hypersensitivity of hamster cells towards mitomycin C and cisplatin

✍ Scribed by Florence Larminat; Gilles Cambois; Małgorzata Z. Zdzienicka; Martine Defais


Book ID
117109844
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
135 KB
Volume
437
Category
Article
ISSN
0014-5793

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Activation of Src, which has an intrinsic protein tyrosine kinase (PTK) activity, has been demonstrated in human solid tumors, such as colorectal and breast cancers. To investigate the role of activated Src in drug resistance, we evaluated the effect of v-src on the resistance to various anti-cancer