Lack of correlation between peripheral blood lymphokine-activated killer (lak) cell function and clinical response in patients with advanced malignant melanoma receiving recombinant interleukin 2
✍ Scribed by A. K. Ghosh; H. Dazzi; N. Thatcher; M. Moore
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 634 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
A phase-1/11 study of recombinant interleukin 2 (rll-2) was performed in 31 melanoma patients. The first dose of rlL-2 was given intrasplenically followed 4 hr later by an i.v. dose and 3 further i.v. doses on alternate days. Three courses of treatment were planned at 3-week intervals. The maximum tolerated single dose was I I X 10' Cetus Ulm'. Haematological and immunological data were available on 20 patients. Post-treatment response to rll-2 therapy was evident from (i) a rapid depletion of peripheral blood lymphocytes (PBL) with a rebound at 4-7 days (2 times pre-treatment values); (ii) an increase in the number of 11-2 receptor-positive lymphocytes (4-1 5 times pre-treatment values); (iii) an increase in the number of "positive" patients with cytotoxic (anti-K562) peripheral blood mononuclear cells (PBMC) from 30% to 80%; (iv) amplified killing of K562 by positive patients in relation to pre-treatment values; and (v) the induction of PBMC cytotoxicity (in 45% of patients) against the NK-resistant, LAK-sensitive target, Me1 I. Partial clinical responses to rll-2 treatment were observed in 4 patients, but these were not reflected in the PBMC LAK activity or the other parameters examined.