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Lack of correlation between mms-toxicity in larvae and in adults of mutagen-sensitive mutants of drosophila melanogaster

✍ Scribed by Graf, U. ;Würgler, F. E.

Publisher: Wiley (John Wiley & Sons)
Year: 1979
Weight: 523 KB
Volume: 1
Category: Article
ISSN: 0192-2521
DOI: 10.1002/em.2860010306

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✦ Synopsis

Adult males of 20 different stocks of Drosophila melanogaster, including 16 with various X-linked mutagen-sensitive mutations, were tested for sensitivity to the lethal action of methyl methane sulfonate (MMS) in a continuous feeding experiment. It was impossible to establish a correlation between MMS-toxicity in adults and MMS-toxicity in larvae. In addition, experiments to examine the fertility of MMS-treated flies of four mutagen-sensitive strains and one wild-type strain were performed. These experiments demonstrated that the spermatogonia of mei-9L1 and mei-41D5 in larvae and in adults are more sensitive to MMS than the spermatogonia of the wild-type strain or the other two mutagen-sensitive strains.

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