Lack of correlation between Marek's disease tumor induction and expression of endogenous avian RNA tumor virus genome
✍ Scribed by B. W. Calneck; L. N. Payne
- Book ID
- 102863333
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- French
- Weight
- 846 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Infection with Marek's disease virus (MDV) and subsequent tumor development failed to induce the expression of endogenous avian RNA tumor virus genome in Line‐151 and Line‐7 chickens which lacked such expression at 1 day of age. Titers of avian leukosis virus (ALV) group‐specific (gs) antigen detected by the COFAL test and expression of chick helper factor (chf) activity remained relatively constant in birds which expressed these genome functions at hatching time. Endogenous ALV belonging to the E‐subgroup was isolated from two of 50 birds; both were controls not exposed to MDV. There was no correlation between expression of ALV genome (gs or chf) at 1 day of age and the rate of tumor development subsequent to MDV infection. It was concluded that MDV infection can induce tumors without the participation of endogenous ALV genome.