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Lack of augmenting effect of interferon-γ on dengue virus multiplication in human peripheral blood monocytes

✍ Scribed by Dr. Nopporn Sittisombut; Niwat Maneekarn; Kwanjai Viputtikul; Jiraporn Supawadee; Amornrat Kanjanahaluethai; Watchara Kasinrerk

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
647 KB
Volume
45
Category
Article
ISSN
0146-6615

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✦ Synopsis

The effect of interferon-? (IFN-y) on dengue virus multiplication in human peripheral blood monocytes was investigated. Enriched monocytes were treated with IFN-y and then infected with dengue virus type 2 either directly or in the presence of optimal infection-enhancing levels of antibodies. Pretreatment of monocytes from dengue-immune donors with 100 IU/ml of IFN-y caused 12-to 97-fold and 13-to 137-fold reduction of virus yields at 24 hr after infection in the absence and presence of an anti-flavivirus monoclonal antibody, respectively. IFN-y also diminished virus yields when infection of monocytes from a donor who lacked anti-dengue antibody was enhanced 40-fold. The percentage of infected monocytes in IFN-y-pretreated cultures was similarly reduced. Dominance of the antiviral effect of IFN-y in monocytes is in contrast to an augmenting effect previously observed in the promonocytic cell line U937.

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