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Lack of association of APOE and tau polymorphisms with dementia in Parkinson’s disease

✍ Scribed by Mario Ezquerra; Jaume Campdelacreu; Carles Gaig; Yaroslau Compta; Esteban Muñoz; Maria Jose Martí; Francesc Valldeoriola; Eduardo Tolosa


Book ID
116770910
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
128 KB
Volume
448
Category
Article
ISSN
0304-3940

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Mice with targeted disruptions in the iron-responsive binding protein 2 (IRP2) gene accumulate iron in distinct regions of the brain and develop neurodegenerative characteristics resembling Parkinson's disease after 6 months of age. To determine whether polymorphisms in IRP2 predispose humans to Par