Genetic anticipation, a phenomenon characterized by increased severity of symptoms and earlier age at onset of a disease in successive generations, is believed to be present in schizophrenia. In several neurodegenerative diseases showing anticipation, the mutation causing the disease is an expanded
Lack of association between schizophrenia and theCYPZD6 gene polymorphisms
β Scribed by Pirmohamed, Munir ;Wild, Martin J. ;Kitteringham, Neil R. ;O'Brien, Kay ;Buchan, Iain E. ;Back, David J. ;Park, B. Kevin
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 150 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0148-7299
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Potential contributions of dopamine transporter (DAT) gene variants to delusional disorder were investigated using association analysis. DAT gene VNTR polymorphisms were assessed in 61 delusional patients and 54 normal controls. No differences were found in either genotypic or allelic distributions.
## Abstract Schizophrenia is a complex disorder with a multifactorial polygenic inheritance with several genes conferring susceptibility at many genetic locations, each with a small effect. An attractive candidate gene for schizophrenia is the catecholβ__O__βmethyltransferase (__COMT__) gene, which