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Lack of association between juvenile myoclonic epilepsy and GABRA5 and GABRB3 genes

✍ Scribed by Guipponi, Michel; Thomas, Pierre; Girard-Reydet, Claire; Feingold, Josué; Baldy-Moulinier, Michel; Malafosse, Alain

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
137 KB
Volume
74
Category
Article
ISSN
0148-7299

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✦ Synopsis

Alpha5 and beta3 GABA A receptor genes are major candidates for epilepsy, as they code for subunits of the most important human inhibitory neurotransmitter. Moreover, they are located within a region of the human genome previously implicated in disorders including epilepsy. We carried out an association study between dinucleotide repeat polymorphisms in these two genes and juvenile myoclonic epilepsy (JME). JME is the most common idiopathic epilepsy and is characterized by a complex mode of inheritance. We did not find significant differences between controls and patients for allele or genotype frequencies. Am.

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