Lack of 12-O-tetradecanoylphorbol-13-acetate responsiveness of ornithine decarboxylase introns which have AP-1 consensus sequences

Non-Ap-1 tumor promoter 12-O-tetradecano

Non-Ap-1 tumor promoter 12-O-tetradecanoylphorbol-13-acetate-responsive sequences in the human ornithine decarboxylase gene

✍ Yong-Joo Kim; Huichin Pan; Ajit K. Verma 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 935 KB

## Abstract To define the mechanisms of 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced transcription of the ornithine decarboxylase (ODC) gene, we isolated a genomic clone (hODC41 B) of ODC from a human leukocyte genomic DNA library. The restriction endonuclease map, in comparison with the