Labial salivary gland biopsy for diagnosis of amyloid polyneuropathy

✍ Scribed by Emmanuèle Lechapt-Zalcman; François-Jérôme Authier; Alain Creange; Marie-Catherine Voisin; Romain K. Gherardi

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 184 KB
• Volume: 22
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/(sici)1097-4598(199901)22:1<105::aid-mus15>3.0.co;2-o

✦ Synopsis

Biopsies of peroneal nerve and labial salivary gland (LSG) were performed in 32 patients with polyneuropathy of unknown origin. Amyloid deposits were detected in 7 LSG (transthyretin = 5; amyloid, light chain derived = 2) and 6 nerve biopsies. Familial amyloid and light chain amyloid polyneuropathies were subsequently confirmed by relevant tests. We propose that LSG biopsy, a minimally invasive test that may document both sicca syndrome and amyloidosis, should be systematically performed in the investigation of patients with axonal polyneuropathies.