✦ LIBER ✦
Labelled compounds of potential biological interest VII. Synthesis of 3-deoxy-D-manno-[1-14C]octulosonic acid (D-manno-KDO) of high specific activity
✍ Scribed by Göran Bondesson; Ingrid Fagervall; Tamas Gosztonyi; Anita Jansson; Annesophie Ohlberger; Astra Läkemedel Ab
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- French
- Weight
- 290 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The preparation of the title compound from 2‐deoxy‐D‐manno‐heptose with potassium [^14^C] cyanide followed by subsequent oxidation is reported. Frequent use of HPLC has made it possible to follow and optimize the different reaction steps. The synthesis was carried out on the millimole level and the product had a specific activity of 50 mCi/mmol.