Labeling with 131I of chloroquine-analogues for the detection of ocular melanoma

✍ Scribed by Cees N. M. Bakker; Frans M. Kaspersen

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: French
• Weight: 437 KB
• Volume: 15
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580150181

✦ Synopsis

Electrophilic iodination of chloroquine with by the chloramine-T method results in labeled 3iodochloroquine (maximum yield 30%) and a number of other labeled quinolines. This method also gives 3-chlorochloroquine in mass amounts. Higher yields (up to 60%) of labeled 3-iodochloroquine are obtained by isotopic exchange with 1311-iodide as its phosphate-salt.