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Labeling of fusion proteins of O6-alkylguanine-DNA alkyltransferase with small molecules in vivo and in vitro

✍ Scribed by Antje Keppler; Maik Kindermann; Susanne Gendreizig; Horst Pick; Horst Vogel; Kai Johnsson

Book ID
116986422
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
484 KB
Volume
32
Category
Article
ISSN
1046-2023

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## Abstract __O__^6^‐alkylguanine‐DNA alkyltransferase (MGMT) represents the first line of defense against the toxic, mutagenic and carcinogenic effects of __O__^6^‐alkylguanine adducts in DNA. These adducts mediate the biological activity from a series of alkylating agents, such as the tobacco‐spe