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Labeling anti-HER2/neu Monoclonal Antibodies with 111 In and 90 Y Using a Bifunctional DTPA Chelating Agent

✍ Scribed by Blend, Michael J.; Stastny, Jerry J.; Swanson, Steven M.; Brechbiel, Martin W.

Book ID: 120024971
Publisher: Mary Ann Liebert
Year: 2003
Tongue: English
Weight: 204 KB
Volume: 18
Category: Article
ISSN: 1084-9785
DOI: 10.1089/108497803322285107

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Optimum labelling of monoclonal antibody

Optimum labelling of monoclonal antibody 3El.2 with 111in using a bifunctional chelate

✍ R. R. Reilly; G. G. Ege 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 379 KB

Monoclonal antibody 3E1.2 was coupled with the bifunctional chelate, cyclic DTPA anhydride, at molar ratios (cOTPAA:3E1.2) of 1:1, lO:l, 1OO:l and 1oOO:l. The desired substitution level of less than one mol of D"PA/bl of 3E1.2 was achieved at a molar ratio of 1O:l and a coupling efficiency of 9.9t3.