La Substitution Nucléophile Activée en Série Aromatique V. Réactivité Des 2-, 3- et 4- Chloropyridine N-Oxydes Avec la Piperidine dans le Méthanol

✍ Scribed by G. Coppens; F. Declerck; C. Gillet; J. Nasielski

• Publisher: Wiley (John Wiley & Sons)
• Year: 2010
• Weight: 417 KB
• Volume: 70
• Category: Article
• ISSN: 0037-9646
• DOI: 10.1002/bscb.19610700903

✦ Synopsis

Abstract

The rates of reaction of 2‐, 3‐ and 4‐chloropyridine N‐oxides towards 1 M piperidine in methanol have been measured conductimetrically. Apparent unimolecular rate constants at 80°C are respectively 3,70.10^−4^, 1,04.10^−7^ and 1,02.10^−4^ sec^−1^. The reactivity sequence 2 > 4 >> 3 is discussed in terms of competing inductive and “built‐in solvation” effects.