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L-(S)-Erythrulose: The synthesis of (R)-1,2,4-butanetriol and of some related C4 chirons.

✍ Scribed by E. Van der Eycken; H. De Wilde; L. Deprez; M. Vandewalle

Book ID: 104227920
Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 151 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)96619-x

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✦ Synopsis

L-(S)-Erythrulose can easily be transformed into (R)-1,2,4-butanetriol and related C4 c_hiral building blocks. A formal synthesis of (-)GABOB is presented. Also the formation o 3 methylene-1,2,4-butanetriol derivatives is described.

Because L-(S)-erythrulose 1 recently became more readily available 2 it can be considered as a valuable new "chiral pool" compound. In the preceeding publication3 1 has been used as a precursor for the more difficultly accessible S-enantiomer of the glyceraldehyde acetonides4.

However, the most salient feature of 1. undoubtedly consists of its potential as a C4-

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