L-myc polymorphism in cancer patients, healthy blood donors and elderly, tumor-free individuals in Russia
✍ Scribed by Alexandr V. Togo; Evgeny N. Suspitsin; Maxim Yu. Grigoriev; Eduard S. Ilyushik; Maria B. Karpova; Kaido P. Hanson; Evgeny N. Imyanitov
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 57 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
L-myc polymorphism was investigated in 95 breast cancer (BC), 63 colorectal cancer (CC) and 58 lung cancer (LC) patients, as well as in 122 healthy, middle-aged blood donors (HBDs) and 184 elderly, tumor-free individuals. The occurrence of the S allele in the BC cohort (57%) was significantly higher than that in middle-aged, healthy females (41%) and elderly, non-affected women (47%), implying involvement of the L-myc genotype in BC susceptibility (age-adjusted OR ؍ 1.74, 95% CI 1.11-2.73, p ؍ 0.016). L-myc allele distribution in CC and LC was similar to that in controls. Contrary to earlier reports, L:S allele frequencies ratio in elderly blood donors (EBDs) did not significantly differ from that in HBDs (0.49: 0.51 and 0.54:0.46, respectively). However, the S allele had a tendency to be over-represented among elderly compared with middle-aged smokers (55% vs. 44%; OR ؍ 1.57, 95% CI 0.98 -2.50, p ؍ 0.059), which implies that it may be linked with tolerance to smoking effects.