l-Glutamate-induced swelling of cultured astrocytes is dependent on extracellular Ca2+
β Scribed by Koyama, Yutaka; Baba, Akemichi; Iwata, Heitaroh
- Book ID
- 123550496
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 276 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0304-3940
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The effects of glutamate and its agonists and antagonists on the swelling of primary astrocytes were studied. Glutamate (Glu), aspartate (Asp), homocysteate (HCA), and quisqualate (Quis) at 1 mM concentration caused a significant increase in astrocytic swelling as measured by the 3-0-methyl-['4C]-gl
## Abstract Generation of reactive oxygen species (ROS) in brain tissue leads to neurodegeneration. The major source of ROS is the mitochondrial respiratory chain. We studied regulation of Ca^2+^ level, mitochondrial potential, and ROS generation in defined mixed hippocampal cell cultures exposed t