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l-dopa-induced reversal in striatal glutamate following partial depletion of nigrostriatal dopamine with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

✍ Scribed by H.K. Holmer; M. Keyghobadi; C. Moore; C.K. Meshul


Book ID
116787310
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
442 KB
Volume
136
Category
Article
ISSN
0306-4522

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## Abstract Administration of the neurotoxicant 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) to C57BL/6 mice targets nigrostriatal dopaminergic neurons, leading to cell death and the depletion of striatal dopamine. After MPTP lesioning in young adult mice, surviving nigrostriatal dopaminergi