L-dopa causes an acute, partial and reversible reversal of denervation-induced supersensitivity of striatal dopaminergic receptors
✍ Scribed by S. Ferre; M. Casas; A. Cobos; C. Garcia; F. Jane; J. M. Grau
- Book ID
- 104668771
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 332 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0033-3158
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✦ Synopsis
Denervation-induced supersensitivity of the striatal dopamine receptors can be quantified by the turning behaviour induced by apomorphine. With this experimental model we found that high-dose L-dopa/carbidopa administration reduced this supersensitivity. This effect was seen on the 1st day and did not alter over 5 or 10 days of treatment, but disappeared when medication was discontinued. The degree of reduction was the same, independent of the dose and period of administration. This effect could provide a useful model for studying the phenomenon of the irreversibility of the supersensitivity of the striatal dopamine receptors.