Köbberling-Dunnigan syndrome: A rare cause of generalized muscular hypertrophy
✍ Scribed by Susanne Wildermuth; Stephanie Spranger; Matthias Spranger; Friedhelm Raue; Hans-Michael Meinck
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 521 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0148-639X
No coin nor oath required. For personal study only.
✦ Synopsis
A 36-year-old woman presented with muscle hypertrophy (particularly of the calves) since puberty, occasional muscle cramps, a musculine habitus, and a loss of subcutaneous fat on limbs and trunk sparing her face, neck, and vulva. Multiple lipomas were found on her trunk, and acanthosis nigricans on her neck. Laboratory testing revealed hyperlipidemia and pathological glucose tolerance with hyperinsulinemia. Physical and laboratory findings are consistent with Kobberling-Dunnigan syndrome, a rare inherited form of lipoatrophy. The patient's mother had the same body habitus and insulindependent diabetes mellitus. These cases suggest that partial lipodystrophy also affects muscle and is a cause of genuine muscular hypertrophy. 0 1996