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Kynurenate antagonism of domoic acid-provoked EEG seizure activity in the mouse

โœ Scribed by C. Pinsky; R. Bose; M. del Campo; G.R. Sutherland; G.B. Glavin; J.E. Bruni


Book ID
115885242
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
209 KB
Volume
183
Category
Article
ISSN
0014-2999

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This study evaluated the anticonvulsant activity of D-cycloserine against maximal electroshock seizures in rats. Systematically administered D-cycloserine (i.p.) inhibited maximal electroshock-induced tonic hindlimb extension in a dose-dependent manner with an ED50 of 153 mg/kg. No neurological defi