Kupffer cells are a major source of increased platelet activating factor in the CCl4-induced cirrhotic rat liver

Suppression of lipopolysaccharide-induce

Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat kupffer cells

✍ Shamimunisa B. Mustafa; Brent D. Flickinger; Merle S. Olson 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 208 KB

Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe