Because the role of Kupffer cells (KCs) in liver transplantation (LT) tolerance is not well understood, we investigated their role in liver allograft acceptance in rats. Male Sprague-Dawley rats were randomly assigned to either an LT group or a transplantation group pretreated with GdCl 3 (Gd group)
Kupffer cells: Another player in liver tolerance induction
β Scribed by Mary Lou Everett; Bradley H. Collins; William Parker
- Book ID
- 111723366
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 39 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1527-6465
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π SIMILAR VOLUMES
The liver is known to favor the induction of immunological tolerance rather than immunity. Although Kupffer cells (KC) have been indicated to play a role in liver tolerance to allografts and soluble antigens, the mechanisms involved remain unclear. We hypothesized that KCs could promote immune toler
The liver appears to play an important role in immunological tolerance, for example, during allo-transplantation. We investigated tolerance mechanisms in the model of concanavalin A (ConA)-induced immune-mediated liver injury in mice. We found that a single injection of a sublethal ConA dose to C57B