Kupffer cells and hepatocyte metabolism: A two-way street?

✍ Scribed by Elizabeth E. Powell; Michael J. Waters; Julie R. Jonsson

• Book ID: 102242083
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 71 KB
• Volume: 49
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.22801

✦ Synopsis

rived growth factor appears also to act on vessel stability and angiogenesis. 9 Interestingly, FGF lacks the classic signal sequence for secretion, and this suggests that its release may be mediated upon EC damage and death. 10 If DF does indeed regulate FGF signaling, how then can this be related to the physiology? One possibility is that EC activation and injury result in high levels of FGFs being released at the site of injury. DF, acting to enhance FGF signaling, could stabilize the vasculature, promote EC survival, and allow repair and regrowth through combination with other factors because studies have demonstrated that patent functional vessels require the coordinated interactions of multiple angiogenic factors.

Thus, this work suggests that the efficacy of DF may lie in its ability to regulate multiple pathways involved in VOD (the inflammatory, thrombotic, and angiogenic pathways), and this increases the robustness of its clinical benefit.