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Krox-20: A candidate gene for the regulation of pattern formation in the hindbrain

✍ Scribed by Gilardi, P.; Schneider-Maunoury, S.; Charnay, P.

Book ID
122929358
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
863 KB
Volume
73
Category
Article
ISSN
0300-9084

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Krox-20 and Krox-24 (Egr-1) encode closely related zinc finger transcription factors, which interact with the same DNA target sequences. Krox-20 is required for myelination in the peripheral nervous system. Using lacZ knock-in mutant mouse lines as well as immunohistochemical analyses, we have studi