Kobophenol A, a unique tetrastilbene from Carex kobomugi Ohwi (Cyperaceae)

✍ Scribed by Jun Kawabata; Satoshi Ichikawa; Hideyuki Kurihara; Junya Mizutani

• Book ID: 104233098
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 244 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)80655-9

✦ Synopsis

An antimicrobial novel tetrastilbene named kobophenol A (1) has been isolated from Carex kobomugj Ohwi (Cyperaceae) together with previously known oligostilbenes, miyabenol C ( 2) and e-viniferin (3). The structure of 1 has been determined on the basis of its spectroscopic and chemical properties.

There have been a number of oligostilbenes found in Dipterocarpaceae, I) Vitaceae,') Cyperaceae3) and Gnetaceae,4) so far, most of which are composed of two to four resveratrol (3,5,4'-trihydroxpstilbene) units, and some of them exhibit antimicrobial activity. Recently, we disclosed that some Carex spp. (Cyperaceae) were rich in a new type of oligostilbenes named miyabenols. 5, We now report the isolation and structure elucidation of a novel tetrastilbene, kobophenol A (l), having a unique 2,3,4,5-tetraaryltetrahydrofuran skeleton, from subterranean parts of Carex kobomugi Ohwi.

Fresh roots and rhizome of C. kobomugi (1OOg) collected at the seashore of Atsuta-mura were extracted with methanol. The methanol extracts were fractionated by a series of