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Knowledge-Based Tailoring of Gelatin-Based Materials by Functionalization with Tyrosine-Derived Groups

✍ Scribed by Axel Thomas Neffe; Alessandro Zaupa; Benjamin Franklin Pierce; Dieter Hofmann; Andreas Lendlein

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
406 KB
Volume
31
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

Molecular models of gelatin‐based materials formed the basis for the knowledge‐based design of a physically cross‐linked polymer system. The computational models with 25 wt.‐% water content were validated by comparison of the calculated structural properties with experimental data and were then used as predictive tools to study chain organization, cross‐link formation, and estimation of mechanical properties. The introduced tyrosine‐derived side groups, desaminotyrosine (DAT) and desaminotyrosyl tyrosine (DATT), led to the reduction of the residual helical conformation and to the formation of physical net‐points by π–π interactions and hydrogen bonds. At 25 wt.‐% water content, the simulated and experimentally determined mechanical properties were in the same order of magnitude. The degree of swelling in water decreased with increasing the number of inserted aromatic functions, while Young's modulus, elongation at break, and maximum tensile strength increased.

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