Knowledge-based potentials in protein design
โ Scribed by Alan M Poole; Rama Ranganathan
- Book ID
- 113883104
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 191 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0959-440X
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๐ SIMILAR VOLUMES
Knowledge-based potentials can be used to decide whether an amino acid sequence is likely to fold into a prescribed native protein structure. We use this idea to survey the se-quence}structure relations in protein space. In particular, we test the following two propositions which were found to be im
We discuss the derivation of atomic-level potentials of mean force from the known protein structures and their applicability for structural evaluation applications. In the derivation process, rigorous density estimation methodology is used to estimate the probability density functions (PDFs) for the