✦ LIBER ✦
Knot what we thought before: the twisted story of replication
✍ Scribed by Lisa Postow; Brian J. Peter; Nicholas R. Cozzarelli
- Book ID
- 101298383
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 82 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
DNA replication requires the unwinding of the parental duplex, which generates (ϩ) supercoiling ahead of the replication fork. It has been thought that removal of these (ϩ) supercoils was the only method of unlinking the parental strands. Recent evidence implies that supercoils can diffuse across the replication fork, resulting in interwound replicated strands called precatenanes. Topoisomerases can then act both in front of and behind the replication fork. A new study by Sogo et al. [