Knoevenagel reaction of malononitrile with methyl ketone followed by double cyclization catalyzed by potassium fluoride-coated alumina

✍ Scribed by Yoshiharu Nakano; Wei-Ying Shi; Yoshiyuki Nishii; Minoru Igarashi

• Publisher: Journal of Heterocyclic Chemistry
• Year: 1999
• Tongue: English
• Weight: 535 KB
• Volume: 36
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570360106

✦ Synopsis

Abstract

Qualitative limitations were presented for a formation reaction of a series of bridged compounds from ketones and malononitrile catalyzed with potassium fluoride‐alumina in acetonitrile [1]. The bridged com pounds were obtained from only unhindered alkyl methyl ketones. The compounds released hydrocarbon to give pyridine derivatives.