Knoevenagel condensation of 2-carbethoxycyclohexanone and malononitrile: Synthesis of 4-cyano-3-ethoxy-1-hydroxy-5,6,7,8-tetrahydroisoquinoline, an isomer of the abnormal product
β Scribed by T.R. Kasturi; V.K. Sharma
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 550 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
The title compounds, new members in the class of tris-annelated benzenes with [2.2.1] bicyclic rings, were obtained in high yields by coupling of 2-bromo-3-trimethyltin-5,6-dimethylenenorborn-2-ene with copper(I) 2-thiophenecarboxylate (CuTC). The syn isomer was reacted with 3 equiv. of the dienophi
Isomeric 1,5-, 1,6-, 1,7-, 2,6-, and 2,7-naphthalenediols react smoothly with benzene at room temperature in the presence of an excess of aluminum bromide to give 5-, 6-, and 7-hydroxy-4-phenyl-1-tetralones and 5-and 6-hydroxy-4-phenyl-2-tetralones, respectively. The mechanism of these reactions is