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KLF1 regulates BCL11A expression and γ- to β-globin gene switching

✍ Scribed by Zhou, Dewang; Liu, Kaimao; Sun, Chiao-Wang; Pawlik, Kevin M; Townes, Tim M


Book ID
109914639
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
263 KB
Volume
42
Category
Article
ISSN
1061-4036

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We report a study of four families of Italian origin in which heterocellular HPFH is inherited linked to beta thalassemia over two or three generations. The HPFH + beta thalassemia carriers showed thalassemic blood pictures and elevated HbF and F-cell number without increase in the HbF/F-cell conten