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KIT and RAS signalling pathways in testicular germ cell tumours: new data and a review of the literature

✍ Scribed by N. C. Goddard; A. McIntyre; B. Summersgill; D. Gilbert; S. Kitazawa; J. Shipley


Book ID
108785340
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
743 KB
Volume
30
Category
Article
ISSN
0105-6263

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Somatic KIT mutations occur predominantl
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## Abstract Mutations in the __KIT__ gene occur in ∼8% of all testicular germ cell tumors (TGCT) and __KIT__ is the most frequently mutated known cancer gene. One report has shown that 93% of patients with bilateral disease have a mutation at codon 816 of the __KIT__ gene. Importantly, this suggest