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KIR matching in hematopoietic stem cell transplantation

✍ Scribed by Jean-Denis Bignon; Katia Gagne

Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
135 KB
Volume
17
Category
Article
ISSN
0952-7915

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✦ Synopsis

Although the key role of MHC-restricted T lymphocytes in hematopoietic stem cell transplantation (HSCT) has been known for a long time, recent data have focused on complementary or alternative effector cell populations, and in particular on NK cells. Spontaneously generated NK cell alloreactivity from stem cell grafts involves specific interactions between NK receptors, including killer immunoglobulin-like receptors (KIRs) and their MHC class I ligands. The combined effects of HLA and KIR polymorphic genes might explain discrepancies in the impact of donor-recipient matching observed in HSCT.

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