Kinetics of voltage-dependent sodium current in cultured frog Schwann cells
โ Scribed by Miyazaki, Takefumi; Tasaka, Junko; Sakai, Saeko; Hashiguchi, Toshio; Tosaka, Tsuneo
- Book ID
- 123336358
- Publisher
- Elsevier Science
- Year
- 1991
- Weight
- 106 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0921-8696
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Previous experimental observations indicate that inhibition of voltage-dependent K+ currents suppresses proliferation of normal Schwann cells. In the present study we tested the opposite relationship, i.e., whether Schwann cells from tumors with abnormally high rates of proliferation would have an i
Characteristics of voltage-dependent currents in cultured frog Schwann cells were investigated by the whole-cell clamp technique. An inward current was detectable a t a membrane potential level more positive than -50 mV and reached a maximum value at about -10 mV, while no rectifying channel was pre