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Kinetics of thermal [1,7a]-sigmatropic shift of hexafluoro vitamin D3 and vitamin D3 derivatives. Evaluation of conformations of the A ring affected by 1-OH and 3-OH groups.

✍ Scribed by Jun-etsu Igarashi; Masahiko Ikeda; Makoto Sunagawa

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 244 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00245-4

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✦ Synopsis

The quantitative evaluation of the [1,7a]-sigmatropic rearrangement of vitamin D 3 and its analogs affected by the conformations of the A ring using the 1H-NMR method was described. Although the side chain of the D ring had no effect on the hydrogen migration, the rearrangement was influenced by the hydroxy groups of the A ring.

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