## Abstract To investigate the potential utility of mechanical loading in articular cartilage tissue engineering, porous type II collagen scaffolds seeded with adult canine passaged chondrocytes were subjected to static and dynamic compressions of varying magnitudes (0β50% static strain) and durati
β¦ LIBER β¦
Kinetics of the chondrocyte biosynthetic response to compressive load and release
β Scribed by Gray, Martha L.; Pizzanelli, Angelina M.; Lee, Raphael C.; Grodzinsky, Alan J.; Swann, David A.
- Book ID
- 122991120
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 942 KB
- Volume
- 991
- Category
- Article
- ISSN
- 0304-4165
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## Abstract Mechanical loading plays a fundamental role in the physiological and pathological processes of articular cartilage. The application of dynamic compression to chondrocytes cultured in agarose, downregulates the release of nitric oxide (NO) and enhances cell proliferation and proteoglycan