Kinetics of the addition of lithium reagents to ketones

✍ Scribed by Stanley G. Smith; W.A. Noyes

• Book ID: 104236306
• Publisher: Elsevier Science
• Year: 1966
• Tongue: French
• Weight: 143 KB
• Volume: 7
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)84173-3

✦ Synopsis

jiace lithium reagents and Grlgnard reqcnts ore of considerable interest, (3) it is desirable to have quantitative measures of their relative reactivity in typical systems. In this paper, the kinetics of the addition of the lithiw reagent prepared from methyl bromide and lithium (4) in diethyl ether to 2,4-dimethyl-4'-methyhercaptobenzophenone (I) are presented. These data may be compared with those reported earlier for the reaction of the corresponding Grignard relent. (5) The kinetics were measured spectroscopically by following the change in absorbance of the ketone using a stopped flow technique (6) with lithium reagent concentrations from 0.014 to 0.15 M and ketone concentrations in the range of 1 to 3 x low3 E at 25.0' in diethyl ether. The data,