A new method is proposed for the determination of the enthalpy and entropy changes of nonionic origin upon conformational transition of linear biopolyelectrolytes in solution. For all transition midpoints, defined by given temperature and ionic strength, the total free energy change of the system is
Kinetics of synthesis and/or conformational changes of biological macromolecules
β Scribed by A. C. Pipkin; J. H. Gibbs
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1966
- Tongue
- English
- Weight
- 692 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0006-3525
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β¦ Synopsis
The analogy, in both the thermodynamics and the kinetics, of reversible polymerizations on templates (in the case wherein these are catalyzed by exoenzymes) to helix-coil transitions (in the case where these proceed only from one end of each macromolecular chain) is presented. A suggestion, based on this analogy, is made concerning the possible nature of biological control of synthesis of macromolecules (enzyme induction and repression). The equations governing the kinetics of these one-dimensional cooperative processes are presented and their solutions discussed.
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