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Kinetics of phosphorylation of the SH2-containing domain of phospholipase Cγ1 by the epidermal growth factor receptor

✍ Scribed by Israel Posner; Alexander Levitzki


Book ID
115929442
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
446 KB
Volume
353
Category
Article
ISSN
0014-5793

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Regulation of the epidermal growth facto
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The receptor for epidermal growth factor (EGF) is a glycosylated transmembrane phosphoprotein that exhibits EGF-stimulable protein tyrosine kinase activity. On EGF stimulation, the receptor undergoes a self-phosphorylation reaction at tyrosine residues located primarily in the extreme carboxyl-termi