Charge migration in DNA has attracted significant attention because of its importance for DNA damage and repair. Several experimental and theoretical studies have focused on the mechanism and distance dependence of charge migration in DNA. Ly et al. suggested [1,2] that the migration of a positive charge in DNA occurs by hopping [3,4] from one base to a neighboring base, while Barton and co-workers considered that charge transport in DNA occurs coherently, by a superexchange mechanism, through the p-stack of the DNA base pairs. [5,6] The rate of charge transfer (k CT ) by superexchange should follow the distance (R) dependence in Equation ( 1). Experiments on diverse donor-bridge-acceptor systems yielded a large scatter in the magnitude of the b values, implying large variances in the conductive properties. [6±14] Recent studies suggest a more complex interplay between both mechanisms. [15±22] In particular, Giese and co-workers have provided evidence for charge hopping between individual bases, [20±22] which is also in line with previous experimental observations by Barton and coworkers [11,18] as well as Schuster and co-workers. [16] Jortner and co-workers have described a hopping mechanism, for which a weaker distance dependence for charge migration according to Equation ( 2) is expected, [23±25] where N,