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Kinetics of inactivation of 4-aminobutyrate aminotransferase by 3-bromopyruvate

โœ Scribed by Blessinger, K. J.; Tunnicliff, G.

Book ID
120372835
Publisher
NRC Research Press
Year
1992
Tongue
English
Weight
578 KB
Volume
70
Category
Article
ISSN
0829-8211

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โœ Richard B. Silverman; Gregory T. Olson ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 652 KB

The mechanism of inactivation of gamma-aminobutyric acid aminotransferase (GABA-AT) by L-3-chloroalanine hydroxamate (1) was investigated. Inactivation of [3H]PLP-reconstituted GABA-AT with 1 followed by denaturation gave no PMP or enamine adduct to the PLP; however, a new unknown metabolite was obs