Kinetics of heteronuclear cross-relaxation in dipolar coupled-spin systems: Applications toin vivo measurements

✍ Scribed by Bachert, Peter

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 300 KB
• Volume: 9
• Category: Article
• ISSN: 1043-7347
• DOI: 10.1002/(sici)1099-0534(1997)9:4<227::aid-cmr3>3.0.co;2-0

✦ Synopsis

Signal intensity changes observed in double-resonance experiments on dipolar coupled-spin systems in liquid phase are known as the nuclear Overhauser effect 1 (

) NOE . This article describes the theory of dynamic nuclear polarization of coupled spin-2 nuclei along with the experimental techniques that permit us to observe the kinetics of heteronuclear NOE and that help us to determine the cross-relaxation rate constant. Kinetic effects can be detected in coupled I-S spin ensembles when the period of driving of S spins is varied and the nuclear magnetic resonance signal enhancement of I spins is recorded. Truncated driven and transient NOE experiments on 31 P-1 H and 13 C-1 H spin systems are discussed with particular reference to in vivo applications.