## Abstract Reaction rate constants for the hydrolysis of organic esters and amides were determined at temperatures of 100β240Β°C in aqueous solutions buffered at pH values between 5.5 and 7.3. Experiments are modeled assuming alkaline hydrolysis with a thermodynamic solution model included to accou
Kinetics of fast alkaline hydrolysis of esters
β Scribed by A.K. Nanda; M.M. Sharma
- Publisher
- Elsevier Science
- Year
- 1967
- Tongue
- English
- Weight
- 537 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0009-2509
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β¦ Synopsis
The method of liquid extraction accompanied by fast pseudo-first-order reaction has been used for studying the kinetics of fast alkaline hydrolysis of esters which are sparingly soluble in water. This method, under certain circumstances, could cover a very wide range of second-order rate constants (0.2-10,000 I./g mole xx). The method could also be adopted for studying the alkaline hydrolysis of esters which are solids at ambient conditions and are sparingly soluble in water.
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In alkaline media the 2-, 3-, and Cmonohexanoates of lincomycin rapidly isomerize, each entering into facile equilibrium with the other two, accompanied by hydrolysis of each species to lincomycin. The concentration-time curves of the three esters and of lincomycin as observed in a single experiment
The kinetics of the acid and alkaline hydrolysis of monoflorophosphorous acid has been studied by P-31 NMR and static pH titration over a wide temperature range. The acid catalyzed hydrolysis has a rate constant at 25Β°C equal to 0.35 dm3 mol-l s-l and an activation energy of 53 k J while the alkalin