Kinetics of epidermal growth factor binding and processing in isolated intact rat hepatocytes : Dynamic externalization of receptors during ligand internalization

Amiloride inhibits constitutive internal

Amiloride inhibits constitutive internalization and increases the surface number of epidermal growth factor receptors in intact rat hepatocytes

✍ Ivar P. Gladhaug; Thoralf Christoffersen 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 939 KB

## Abstract In previous experiments the surface expression of epidermal growth factor (EGF) receptors in freshly isolated rat hepatocytes varied temperature‐ and time‐dependently and was depleted by monensin and cycloheximide in a way suggesting that a subpopulation of these receptors are subject t