Kinetics of Elimination of Drugs Possessing High Affinity for the Plasma Proteins
β Scribed by MARTIN, B. K.
- Book ID
- 109645672
- Publisher
- Nature Publishing Group
- Year
- 1965
- Tongue
- English
- Weight
- 196 KB
- Volume
- 207
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/207959a0
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Quantification of protein binding of new chemical entities is an important early screening step during drug discovery and is of fundamental interest for the estimation of safety margins during drug development. In this publication, we describe the development of a new high-throughput assay for the d
## Abstract Silica monoliths in affinity microcolumns were tested for the highβthroughput analysis of drugβprotein interactions. HSA was used as a model protein for this work, while carbamazepine and __R__βwarfarin were used as model analytes. A comparison of HSA silica monoliths of various lengths