Kinetics of decomposition of UV-absorbing intermediate generated during electrochemical oxidation of 6-mercaptopurine at stationary pyrolytic graphite electrode
✍ Scribed by R. N. Goyal; Madhu Shri Verma
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 647 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1075-4261
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✦ Synopsis
Spectroscopic technique coupled with electrochemical oxidation has been used to study the redox-mechanism of 6-mercaptopurine. Electrochemical oxidation of 6-mercaptopurine has been studied in the pH range 2.0-10.0 by linear and cyclic sweep voltammetry, coulometry and constant potential electrolysis. Spectroscopic technique has been used to monitor the clevage of the S -S bond in the UV-absorbing intermediate generated during electrooxidation. The decay has been observed in a pseudo first order reaction. The ultimate products of oxidation in controlled potential electrolysis have been found as 6-mercaptopurine and purine-6-sulfinic acid. Tentative mechanisms for the formation of the products have also been suggested. It is concluded that spectroscopic studies coupled with electrochemical studies provide a uniquely invaluable insight into the redox mechanism of biologically significant molecules.