Kinetics of cellular trafficking and cytotoxicity of 9.2.27-gelonin immunotoxins targeted against the high-molecular-weight melanoma-associated antigen

Immunotoxins directed against the high-m

Immunotoxins directed against the high-molecular-weight melanoma-associated antigen. Identification of potent antibody-toxin combinations

✍ Aslak Godal; Brita Kumle; Alexander Pihl; Siri Juell; Øystein Fodstad 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 631 KB

## Abstract To study factors influencing the cytotoxicity of immunotoxins (ITs), we compared the __in vitro__ cytotoxicity of conjugates in which the plant toxin abrin and the bacterial toxin __Pseudomonas__ exotoxin A (PE) were coupled by 2 different procedures to 2 MAbs, 9.2.27 and NR‐ML‐05, whic